Astros vs. Orioles Prediction and Odds - Sep 22, 2022

The Baltimore Orioles square off with the Houston Astros in MLB action at Oriole Park at Camden Yards on Thursday, beginning at 7:05PM ET.

Kyle Bradish (3-7, 5.05 ERA) will start for the Orioles, up against Justin Verlander (17-3, 1.78 ERA) for the Astros.

Dimers' best betting picks for Astros vs. Orioles, plus game predictions and betting odds, are featured in this article.


Who will win Astros vs. Orioles?

Using cutting-edge machine learning and data, has simulated Thursday's Astros-Orioles MLB matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the Astros a 61% chance of beating the Orioles.

More: Full Betting Guide for Astros vs. Orioles

Astros vs. Orioles Game Odds

  • Run Line: Orioles +1.5 (+100), Astros -1.5 (-115)
  • Moneyline: Orioles +172, Astros -195
  • Total: Over/Under 6.5 (-114/+105)

Run Line, Moneyline and Over/Under

The Orioles are +1.5 underdogs versus the Astros, with +100 at DraftKings Sportsbook the best odds currently available.

For the favored Astros (-1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at -115.

FanDuel Sportsbook currently has the best moneyline odds for the Orioles at +172. That means you can bet $100 to profit $172, earning a total payout of $272, if they win.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Astros at -195, where you can risk $195 to win $100, for a total payout of $295, if they come out on top.

The Over/Under sits at 6.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -114, while BetMGM currently has the best odds for the Under at +105.

As always, make sure you check the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Orioles (+1.5) are a 53% chance of covering the run line, while the Over/Under total of 6.5 runs is a 62% chance of going Over.

More: Track Your Bets via Bet Center

Best Bets for Astros vs. Orioles


Every time you see a 🔥, you know you've found one of Dimers' best free picks of the day across all major pro and college sports.

Our best bets are based on complex simulations and betting intelligence to help you make more informed investments with your state's legal sportsbooks.

While the Astros are more likely to win the game, according to DimersBOT, taking the Orioles moneyline is the best option because of the 2.0% edge found when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen here at is crucial to achieving long-term profitability.

Astros vs. Orioles Prediction

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Dimers has full betting coverage of Thursday's Astros-Orioles matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so keep checking this article for any changes to our betting analysis before Astros vs. Orioles on Thursday September 22, 2022.


Astros vs. Orioles 2022 Game Info

Thursday's game between the Orioles and Astros at Oriole Park at Camden Yards is scheduled to begin at 7:05PM ET.

  • Who: Houston Astros vs. Baltimore Orioles
  • Date: Thursday September 22, 2022
  • Time: 7:05PM ET / 4:05PM PT
  • Venue: Oriole Park at Camden Yards

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Want more MLB analysis like this?

So, you liked our Astros vs. Orioles betting predictions? Awesome. Did you know our MLB Betting News section has a detailed betting preview for every MLB matchup as soon as the sportsbooks release their odds?

That's right, our predictive analytics model then compares those odds (aka Vegas odds) against its own probabilities to find edges in the markets. This allows us to produce the most reliable MLB betting previews and get the jump on the public and the sportsbooks.

It's only a click away, so why not see for yourself?

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.

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