Arizona Cardinals vs. Seattle Seahawks: Experts release early Week 10 preview [2025]

The Arizona Cardinals and Seattle Seahawks will meet in Week 10 of the NFL season at Lumen Field on Sunday, November 9, 2025, starting at 4:05PM ET.

Initial simulations from Dimers' trusted NFL model favor the Seahawks as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Cardinals vs. Seahawks predictions page.

Arizona vs. Seattle early predictions

Leveraging trusted machine learning and analysis, we have simulated the Cardinals vs. Seahawks game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Cardinals 25%, Seahawks 75%
• Predicted final score: Cardinals 18-25 Seahawks
• Spread: Cardinals (+7) 50%, Seahawks (-7) 50%
• Total points (46.5): Over 46%, Under 54%

As of November 3, 2025, these Cardinals-Seahawks figures and predictions reflect the latest data and insights available.

Cardinals vs. Seahawks Week 10 details

The NFL Week 10 matchup between the Seahawks and Cardinals at Lumen Field is scheduled for November 9, 2025.

• Who: Arizona Cardinals vs. Seattle Seahawks
• Date: Sunday, November 9, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Lumen Field

Cardinals vs. Seahawks opening odds

We've researched the best betting odds across America for this Week 10 game, which are listed here:

• Spread: Cardinals +7 (-110), Seahawks -7 (-110)
• Moneyline: Cardinals +280, Seahawks -340
• Total: Over/Under 46.5 (-108/-112)

Odds may continue to move—track live changes via our NFL odds page.

Anytime touchdown scorer predictions

Early NFL player projections for Week 10 highlight the top candidates to score a TD in Cardinals-Seahawks in Week 10:

Arizona Cardinals

• Bam Knight: 46.5% probability
• Trey McBride: 41.6% probability
• Marvin Harrison: 39.7% probability

Seattle Seahawks

• Jaxon Smith-Njigba: 50.8% probability
• Zach Charbonnet: 50.2% probability
• Kenneth Walker: 39.0% probability

Cardinals vs Seahawks player props

Bam Knight is projected to lead rushing for the Cardinals, while Kenneth Walker is expected to pace the Seahawks on the ground.

In the receiving game, our projections favor Arizona's Trey McBride and Seattle's Jaxon Smith-Njigba as the likely leaders for each team.

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Conclusion

We predict the Seahawks, with a 75% win probability, will likely beat the Cardinals in Week 10 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Cardinals vs. Seahawks matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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