49ers vs. Seahawks Prediction, Week 12 Odds, NFL Player Props [2023]

49ers vs. Seahawks Prediction, Week 12 Odds, NFL Player Props [2023]

The Seattle Seahawks will take on the favored San Francisco 49ers in NFL Week 12 action at Lumen Field on Thursday, beginning at 8:20PM ET.

Dimers' full betting preview for this week's 49ers vs. Seahawks matchup includes the latest betting odds, as well as our predictions and best bets.

Today's San Francisco vs. Seattle prediction is sponsored by Bet365, which has a Bet $5, Get $150 in Bonus Bets promo for new customers.

Who Will Win: 49ers vs. Seahawks

Based on high-tech computer power and data, Dimers.com has simulated the outcome of Thursday's 49ers-Seahawks NFL matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, currently gives the 49ers a 72% chance of beating the Seahawks in Week 12 of the NFL season.

More: Get the latest NFL picks

49ers vs. Seahawks Odds

We have sourced the best betting odds in America for this game, which are listed here:

Bet Type 49ers Seahawks
Spread -7 (-110) +7 (-102)
Moneyline -330 +275
Total o43.5 (-110) u43.5 (-110)

Odds are correct at the time of publication and subject to change.

The Seahawks are +7 underdogs against the 49ers, with -102 at DraftKings Sportsbook the best odds currently available.

For the favored 49ers (-7) to cover the spread, BetMGM has the best odds currently on the market at -110.

DraftKings Sportsbook currently has the best moneyline odds for the Seahawks at +275, which means you can bet $100 to profit $275, earning a total payout of $375, if they win.

On the other hand, FanDuel Sportsbook currently has the best moneyline odds for the 49ers at -330, where you can risk $330 to win $100, for a total payout of $430, if they come out on top.

The Over/Under sits at 43.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

According to DimersBOT, the Seahawks (+7) have a 57% chance of covering the spread, while the 43.5-point Over/Under has a 52% chance of going Under.

As always, make sure you check all of the sports betting sites that are available in your state for the best NFL odds and lines.

Best Bets: 49ers vs. Seahawks

By comparing our predictions to the odds listed above, we have identified the best bets to place on this game:


Every time you see a 🔥, that means you've found one of Dimers' best bets of the day across all sports.

Dimers' NFL best bets are based on complex simulations and betting intelligence to bring you the best possible plays every day of the year.

While the 49ers are more likely to win the game, according to DimersBOT, taking the Seahawks moneyline is the best option due to the 1.4% edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges seen on Dimers.com is one of the keys to achieving long-term profitability as a bettor.

49ers vs. Seahawks Prediction

Dimers.com's predicted final score for San Francisco vs. Seattle at Lumen Field in Week 12 has the 49ers winning 24-18.

Click or tap on See Matchup for more information on 49ers vs. Seahawks.


Dimers has full betting coverage of 49ers vs. Seahawks in Week 12, including pregame predictions, betting picks, and live win probabilities.

49ers vs. Seahawks TD Scorers

Who will score the first touchdown in 49ers vs. Seahawks? The data is in.

Listed below are the most likely first touchdown and most likely anytime touchdown scorers for both the 49ers and Seahawks this Thursday.

And you know what, we provide this information to you for FREE to help you choose the best prop picks for Thursday's game.

According to DimersBOT, San Francisco's Christian McCaffrey is most likely to score the first TD in 49ers vs. Seahawks.

DimersBOT gives McCaffrey an 18.9% chance of scoring the first TD at Lumen Field, while the 49ers RB is a 64.2% chance of reaching the end zone at any point in the game.

Scroll down for the complete list of first and anytime TD scorer probabilities.

First Touchdown Scorer Predictions

San Francisco 49ers

Player First Touchdown Probability
Christian McCaffrey 18.9%
Brandon Aiyuk 10.2%
Deebo Samuel 9.1%
George Kittle 8.7%
Elijah Mitchell 3.4%

Seattle Seahawks

Player First Touchdown Probability
Zach Charbonnet 8.7%
Tyler Lockett 7.1%
DK Metcalf 7.0%
Jaxon Smith-Njigba 5.1%
Geno Smith 3.1%

Anytime Touchdown Scorer Predictions

San Francisco 49ers

Player Anytime Touchdown Probability
Christian McCaffrey 64.2%
Brandon Aiyuk 40.9%
Deebo Samuel 36.4%
George Kittle 35.4%
Elijah Mitchell 15.9%

Seattle Seahawks

Player Anytime Touchdown Probability
Zach Charbonnet 35.8%
Tyler Lockett 30.5%
DK Metcalf 30.4%
Jaxon Smith-Njigba 23.1%
Geno Smith 14.7%

49ers-Seahawks Player Props

Here, you will find detailed projections for all of the key offensive players from the 49ers and Seahawks, including passing, rushing and receiving yards.

49ers vs. Seahawks Quarterbacks

Of the starting quarterbacks, the 49ers' Brock Purdy is projected to have a big game with 273 passing yards, while the Seahawks' Geno Smith is expected to throw for 226 yards.

Player Projected Passing Yards
Brock Purdy (SF) 273 yds
Geno Smith (SEA) 226 yds

49ers Rushing

Player Projected Rushing Yards
Christian McCaffrey 79 yds
Elijah Mitchell 14 yds
Brock Purdy 13 yds

Seahawks Rushing

Player Projected Rushing Yards
Zach Charbonnet 70 yds
Geno Smith 14 yds
DeeJay Dallas 11 yds

49ers Receiving

Player Projected Receiving Yards
Brandon Aiyuk 75 yds
George Kittle 52 yds
Deebo Samuel 51 yds
Christian McCaffrey 35 yds
Jauan Jennings 18 yds

Seahawks Receiving

Player Projected Receiving Yards
DK Metcalf 65 yds
Tyler Lockett 52 yds
Jaxon Smith-Njigba 40 yds
Zach Charbonnet 26 yds
Noah Fant 23 yds

Don't forget, DimersBOT updates regularly, so refresh this page for the latest betting analysis before 49ers vs. Seahawks on Thursday November 23, 2023.


49ers vs. Seahawks Preview

The NFL Week 12 game between the Seahawks and 49ers at Lumen Field is scheduled to begin at 8:20PM ET.

How to Bet on 49ers vs. Seahawks

Enjoy Dimers.com and want to keep the site free? Every time you register and bet with a sportsbook featured here, we get paid a small fee.

These fees help us keep Dimers free for all sports fans. So, if you like what you see, support us by joining one of our featured sports betting partners below, including DraftKings Sportsbook, where you get $200 in bonus bets for signing up and bettting $5 on San Francisco vs. Seattle.


This extensive betting preview centers around our 49ers vs. Seahawks prediction and Week 12 odds.

Dimers' predictions are based on 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.

While these 49ers vs. Seahawks picks can help you make informed decisions, it's important that you gamble responsibly and manage your finances effectively.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that leads to a third-party website that we have a commercial relationship with (such as a sportsbook), we may get a referral fee.

More on NFL

Stay up-to-date on the most recent NFL news and our data-led NFL picks and parlays all season long. Plus, our Super Bowl odds give you the most up-to-date projections and the best available odds on the Super Bowl, AFC, NFC, and each division.

Kevin Hansen
Senior Sports Analyst

Kevin Hansen has a track record of delivering high-quality content. He writes about all sports, but his favorites are the NFL, NBA, MLB, and NHL. Kevin enjoys crunching the numbers and using data-driven insights to take on the sportsbooks. The majority of Kevin's time is spent writing about sports betting. His love for data and analytics drove him into the world of sports betting. Finding an edge in sports betting can take a long time, but Kevin believes it is well worth the effort. Kevin is just as passionate about sports as you are, and he empowers fellow bettors to become more educated through simple, actionable betting tips. It can be difficult to navigate the world of sports betting, which is where Kevin comes in to make it as simple as possible for you to pick a winner.

Related Articles

More Articles
More from Dimers
About Dimers
icon 22,000+
Events covered per year
icon 8,000,000+
Our partners