49ers vs. Broncos Week 3 Prediction and Odds - Sep 25, 2022

The Denver Broncos take on the San Francisco 49ers in NFL Week 3 action at Empower Field at Mile High on Sunday, beginning at 8:20PM ET.

Dimers' top betting picks for 49ers vs. Broncos, as well as game predictions, betting odds and touchdown scorer probabilities, are featured below.

This San Francisco vs. Denver betting preview is sponsored by FanDuel Sportsbook, which is currently offering a No Sweat First Bet bonus up to $1,000 for new customers.


Who will win 49ers vs. Broncos?

Based on trusted machine learning and data, Dimers.com has simulated Sunday's 49ers-Broncos NFL game 10,000 times.

Dimers' proven predictive analytics model, DimersBOT, currently gives the 49ers a 57% chance of beating the Broncos in Week 3 of the NFL season.

More: 49ers vs. Broncos Simulated 10,000 Times

49ers vs. Broncos Current Odds

  • Spread: Broncos +1.5 (+100), 49ers -1.5 (-105)
  • Moneyline: Broncos +110, 49ers -118
  • Total: Over/Under 44.5 (-110/-105)

Point Spread, Moneyline and Over/Under

The Broncos are +1.5 underdogs versus the 49ers, with +100 at Caesars Sportsbook the best odds currently available.

For the favored 49ers (-1.5) to cover the spread, FanDuel Sportsbook has the best odds currently on offer at -105.

Caesars Sportsbook currently has the best moneyline odds for the Broncos at +110, which means you can bet $100 to profit $110, earning a total payout of $210, if they win.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the 49ers at -118, where you can risk $118 to win $100, for a total payout of $218, if they come out on top.

The Over/Under sits at 44.5 with Caesars Sportsbook, which currently has the best odds for the Over at -110, while PointsBet currently has the best odds for the Under at -105.

As always, check out the sportsbooks you can bet with in your state for the best NFL odds and lines.

According to DimersBOT, the bookmakers have got it right and both the 49ers and Broncos are a 50% chance of covering the spread, while the Over/Under total of 44.5 points is also considered an equal 50-50 chance of hitting.

More: Predictions for Every NFL Week 3 Game

Best Bets for 49ers vs. Broncos


Dimers' best bets are based on detailed modeling and betting intelligence to bring you the best possible plays every day of the year.

49ers vs. Broncos Prediction

Dimers.com's predicted final score for San Francisco vs. Denver at Empower Field at Mile High in Week 3 has the 49ers winning 23-21.

Click or tap on See Matchup to reveal more.


Dimers has full betting coverage of this week's 49ers-Broncos matchup in Week 3, including pregame predictions, top betting picks, and live win probabilities.

49ers vs. Broncos Player Props

Who will score an anytime touchdown in 49ers vs. Broncos? The data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the 49ers and Broncos, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you choose the best prop picks for Sunday's game.

According to DimersBOT, San Francisco's Deebo Samuel is most likely to score the first TD in 49ers vs. Broncos.

DimersBOT gives Samuel a 12.8% chance of scoring the first TD at Empower Field at Mile High, while the 49ers WR is a 50.0% chance of reaching the end zone at any point in the game.

Scroll down for our full list of first and anytime TD scorer probabilities.


First Touchdown Scorer Probabilities

San Francisco 49ers

  • Deebo Samuel: 12.8% probability
  • Jeff Wilson: 8.0% probability
  • George Kittle: 7.8% probability
  • Brandon Aiyuk: 6.8% probability
  • Jauan Jennings: 4.9% probability

Denver Broncos

  • Javonte Williams: 9.8% probability
  • Courtland Sutton: 8.2% probability
  • Jerry Jeudy: 7.2% probability
  • Melvin Gordon: 6.2% probability
  • Albert Okwuegbunam: 5.2% probability

Anytime Touchdown Scorer Probabilities

San Francisco 49ers

  • Deebo Samuel: 50.0% probability
  • Jeff Wilson: 35.1% probability
  • George Kittle: 34.4% probability
  • Brandon Aiyuk: 29.4% probability
  • Jauan Jennings: 22.1% probability

Denver Broncos

  • Javonte Williams: 41.4% probability
  • Courtland Sutton: 35.9% probability
  • Jerry Jeudy: 32.6% probability
  • Melvin Gordon: 27.5% probability
  • Albert Okwuegbunam: 24.8% probability

49ers-Broncos Projected Player Stats

Of the starting quarterbacks, the 49ers' Jimmy Garoppolo is projected for 243 passing yards. The Broncos' Russell Wilson is expected to throw for 241 yards.

49ers Starting QB

  • Jimmy Garoppolo: 243 projected yards

Broncos Starting QB

  • Russell Wilson: 241 projected yards

49ers Rushing

  • Jeff Wilson: 55 projected yards
  • Deebo Samuel: 25 projected yards
  • Jordan Mason: 20 projected yards

Broncos Rushing

  • Javonte Williams: 59 projected yards
  • Melvin Gordon: 42 projected yards
  • Russell Wilson: 17 projected yards

49ers Receiving

  • Deebo Samuel: 71 projected yards
  • George Kittle: 59 projected yards
  • Brandon Aiyuk: 56 projected yards
  • Jauan Jennings: 23 projected yards
  • Kyle Juszczyk: 16 projected yards

Broncos Receiving

  • Courtland Sutton: 64 projected yards
  • Jerry Jeudy: 57 projected yards
  • Albert Okwuegbunam: 28 projected yards
  • KJ Hamler: 20 projected yards
  • Javonte Williams: 20 projected yards

Don't forget, DimersBOT updates regularly, so refresh this article for any changes to our betting analysis ahead of 49ers vs. Broncos on Sunday September 25, 2022.


49ers vs. Broncos 2022

The NFL Week 3 game between the Broncos and 49ers at Empower Field at Mile High is scheduled to start at 8:20PM ET.

  • Who: San Francisco 49ers vs. Denver Broncos
  • Date: Sunday September 25, 2022
  • Time: 8:20PM ET / 5:20PM PT
  • Venue: Empower Field at Mile High

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What other NFL games are on today?

Now you've got the 411 on 49ers vs. Broncos, take a look at the latest betting predictions for all upcoming NFL games in Dimers' NFL Bet Hub. There you can find probabilities and odds, as well as our best bets for every single NFL matchup.

Want a pick for the Spread? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

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