NFL 2020 Buffalo Bills vs. San Francisco 49ers: Predictions, picks and bets


December 6, 2020 6:44 PM

NFL Predictions from 10,000 simulations

We've got a good one for Monday Night Football as the Buffalo Bills try to keep the momentum going against the San Francisco 49ers.

The 49ers snapped a three-game skid in their last game, beating the Rams in Week 11. They've had the week off but might not be as refreshed as they should be after dealing with COVID-19 restrictions which have resulted in the team having to play their home games out of The Bay. Despite that though, the sportsbooks and our predictive model see this one going down to the wire against a Bills team who have been a force to be reckoned with this season.

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💪 Spread

This one looks like a genuine pick 'em according to the sportsbook. The Bills are 6-5 against the spread so far this season while the 49ers are 5-6.

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🚀 Over/Under

Buffalo games have seen lots of points this year with the over winning out in 7 of their 11 games. Last week their game did go under, however, and the 49ers are on a run of two straight under games of their own. Are the points drying up?


💵 Moneyline

San Francisco go into this one as "home" favorites despite not being at home, but the moneyline is extremely tight and can change before kick-off depending on team news. 


🏈 Dimers' take-out

Buffalo have the better record overall and appears to have the tools to make a nice little postseason run. A loss for the 49ers could almost end their chances of a ticket past the regular season. This promises to be a season-defining match.

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