NFL 2020 San Francisco 49ers vs. New York Giants: Predictions, picks and bets


September 27, 2020 10:11 AM

The Giants will host the 49ers this Sunday with both teams being limited by serious injuries last time out.

The San Francisco 49ers are looking for the New York sweep after taking out the Jets last weekend, while the Giants are looking for their first win of the season.

Will the 49ers or Giants come out on top in this one? NFL Bet Hub predictions below 👇

Predictions based on 10,000+ simulations


Dimers' Suggested Plays

🔥 BEST: Giants +3

☝ Over/Under: Total under 42.5

💵Moneyline: Giants (+145*)

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🔥 BEST: Spread

Giants +3 has a 50% probability

The 49ers were originally instilled as 4.5 favorites, but the teams have drawn closer during the week. We like the Giants to still cover the line.

☝ Over/Under

Total Points Under 42.5 has a 51% probability

Another over/under total in this week's slate of games that our predictive analysis thinks the sportsbooks have gotten right on the money. This one is too close to call. Avoid.

💵 Moneyline

Giants (+145*) to win has a 1.9% edge on the sportsbooks

With the line the equivalent of a field goal, this one could really go either way. We've got the 49ers to win in our predicted scoreline, but the value here is Giants at + money.

🏈 Dimers' take-out

A big game for both teams’ 2020 prospects, look for Jerick McKinnon to get in for six as this one goes down to the wire. If you’re keen for some action, check out the best NFL promos for this week, here.


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*Odds and probabilities correct at time of publishing.