NFL 2020 Arizona Cardinals vs. San Francisco 49ers: Predictions, picks and bets


September 13, 2020 5:28 PM

NFC West rivals face off in week one, with the San Francisco 49ers playing host to the Arizona Cardinals.

Both fan bases have a lot to look forward to this year, with the 49ers hoping to go one better after falling short in Super Bowl LIV, and the Cardinals being led by young gun Kyler Murray.

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Will the 49ers begin this season with a dub or can the Cardinals shock their division rivals? NFL Bet Hub predictions below 👇

Dimers' predictions are based on 10,000 simulations of this particular matchup


Dimers' Suggested Plays

🔥 BEST: Cardinals +6.5
👇 Over/Under: Total points u48.5
💵 Moneyline: 49ers
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🏈 Week 1 NFL Promos here


🔥 BEST: Spread

Cardinals +6.5 has a 56% probability

Although our model currently has the 49er getting up by 8 points, it’s unlikely to be much more than that, meaning the Cardinals are still likely to cover. We’ve got them at a 56% chance covering the spread, which is one of the biggest % ATS we have this weekend.

RELATED: Turn $1 into $100 on the NFL this week! 💰

👇 Over/Under

Total points under 48.5 has a 50% probability

We currently have this one finishing on 48 points which means the over/under is TIGHT. A 50-50 chance here, so if the market shifts from 48.5 either way, make the play.

💵 Moneyline

49ers (-294*) to win has a 72% probability

Not a whole heap of money on offer here but at 72% probability this is basically a must play. For more info on both of these sides, check out our NFC West preview here.

🏈 Dimers' take-out

The 49ers are out for blood this season after the heartbreak of last season’s Super Bowl and we’ve got them starting off the right way with a win. If you’re keen for some action, check out the best Week 1 NFL promos here.


Read our comprehensive online sportsbook reviews here.

*Odds and probabilities correct at time of publishing.