Aug 22, 2026
Braves vs. Brewers prediction: Why Milwaukee is favored to win Saturday's MLB matchup [8/22/2026]
Read Article Cardinals vs. Phillies prediction: Why Philadelphia is favored to win Saturday's MLB matchup [8/22/2026]
Updated: | First published:
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Written by Dave Garofolo, Content Producer
Get St. Louis Cardinals vs Philadelphia Phillies predictions for MLB Saturday.
The Philadelphia Phillies and St. Louis Cardinals are scheduled to meet in MLB action at Citizens Bank Park on Saturday, starting at 6:05 PM ET.
The Phillies will start Andrew Painter (2-8, 6.43 ERA), up against Quinn Mathews (0-1, 3.00 ERA) for the Cardinals.
Dimers' advanced MLB model projects the Phillies as the most likely winner in this Cardinals vs. Phillies prediction.
This article offers an expanded analysis of Saturday's matchup, including best bets and picks.
Cardinals vs. Phillies prediction: Who will win and cover?
Using powerful machine learning and data analysis, we have simulated the result of Saturday's MLB matchup between the Cardinals and Phillies, forming part of our MLB predictions coverage.
Our leading predictive model currently gives the Phillies a 55.3% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 62.4% chance of covering the run line, while the 8.5-run over/under has a 56.8% chance of going over.
Cardinals vs. Phillies odds [8/22/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: Cardinals +1.5 (-170) / Phillies -1.5 (+170)
- Moneyline: Cardinals +122, Phillies -122
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Phillies picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Phillies -1.5 @ +170 via DraftKings
- Moneyline: Phillies @ -122 via Polymarket
- Total: Over 8.5 @ -121 via BetRivers
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Phillies game-day updates and essential details
Saturday's MLB matchup between the Phillies and Cardinals at Citizens Bank Park is scheduled to begin at 6:05 PM ET.
- Who: St. Louis Cardinals vs. Philadelphia Phillies
- Date: Saturday, August 22, 2026
- Time: 6:05 PM ET/3:05PM PT
- Venue: Citizens Bank Park
Conclusion
We predict the Phillies, with a 55.3% win probability, will likely beat the Cardinals in Saturday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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