Aug 19, 2026
Yankees vs. Orioles prediction: Yankees favored to win Wednesday's MLB matchup [8/19/2026]
Read Article Cardinals vs. Reds prediction: Why Cincinnati is favored to win Wednesday's MLB matchup [8/19/2026]
Updated: | First published:
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Written by Dave Garofolo, Content Producer
Get St. Louis Cardinals vs Cincinnati Reds predictions for MLB Wednesday.
MLB action continues on Wednesday at 6:40 PM ET as the St. Louis Cardinals take on the Cincinnati Reds at Great American Ball Park.
The Reds will have Chase Burns (14-2, 2.47 ERA) as their starting pitcher, pitting him against Matthew Liberatore (5-10, 5.07 ERA) for the Cardinals.
Dimers' proven MLB model projects the Reds as the most likely winner in this Cardinals vs. Reds prediction.
This article offers further insights into Wednesday's matchup, including best bets and picks.
For more, dive into Chase Burns' pitching projections.
Cardinals vs. Reds prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Cardinals and Reds, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Reds a 58.7% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 59.4% chance of covering the run line, while the over/under total of 8.5 runs has a 52.1% chance of going over,.
Cardinals vs. Reds odds [8/19/2026]
We have researched the best MLB odds in America for this game, which are listed here:
- Run Line: Cardinals +1.5 (-163) / Reds -1.5 (+156)
- Moneyline: Cardinals +135, Reds -138
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Reds picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Reds -1.5 @ +156 via DraftKings
- Moneyline: Reds @ -138 via FanDuel
- Total: Over 8.5 @ +100 via Polymarket
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Reds game-day updates and essential details
Wednesday's MLB game between the Reds and Cardinals at Great American Ball Park is scheduled to commence at 6:40 PM ET.
- Who: St. Louis Cardinals vs. Cincinnati Reds
- Date: Wednesday, August 19, 2026
- Time: 6:40 PM ET/3:40PM PT
- Venue: Great American Ball Park
Conclusion
We predict the Reds, with a 58.7% win probability, will likely beat the Cardinals in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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