Aug 18, 2026
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Read Article Cardinals vs. Reds prediction: Why St. Louis is favored to win Tuesday's MLB matchup [8/18/2026]
Updated: | First published:
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Written by Dave Garofolo, Content Producer
Get St. Louis Cardinals vs Cincinnati Reds predictions for MLB Tuesday.
The Cincinnati Reds will take on the St. Louis Cardinals, in what is expected to be a tight MLB game, at Great American Ball Park on Tuesday, commencing at 6:40 PM ET.
The Reds will send Andrew Abbott (6-7, 4.13 ERA) to the mound, while the Cardinals are going with Kyle Leahy (9-4, 3.38 ERA).
Dimers' advanced MLB model gives the Cardinals a slight edge with a 51.1% win probability over the Reds.
This article offers a complete Cardinals vs. Reds prediction, including best bets and picks.
Cardinals vs. Reds prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Cardinals and Reds, forming part of our MLB predictions coverage.
Our leading predictive model gives the Cardinals a 51.1% chance of beating the Reds.
According to our model, the Reds (+1.5) have a 60.4% chance of covering the run line, while the 8.5-run over/under has a 52.9% chance of going over,.
Cardinals vs. Reds odds [8/18/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: Cardinals -1.5 (+145) / Reds +1.5 (-147)
- Moneyline: Cardinals -113, Reds +113
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Reds picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Reds +1.5 @ -147 via DraftKings
- Moneyline: Reds @ +113 via Novig
- Total: Over 8.5 @ -104 via Polymarket
According to our MLB best bets, the top play to make on this game is Reds to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Reds game-day updates and essential details
Tuesday's MLB game between the Reds and Cardinals at Great American Ball Park is scheduled to start at 6:40 PM ET.
- Who: St. Louis Cardinals vs. Cincinnati Reds
- Date: Tuesday, August 18, 2026
- Time: 6:40 PM ET/3:40PM PT
- Venue: Great American Ball Park
Conclusion
We predict the Cardinals, with a 51.1% win probability, will likely beat the Reds in Tuesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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