Cardinals vs. Cubs prediction: Why Cubs are favored to win Friday's MLB matchup [8/14/2026]
Get St. Louis Cardinals vs Chicago Cubs predictions for MLB Friday.
The Chicago Cubs will take on the St. Louis Cardinals in MLB action at Wrigley Field on Friday, commencing at 2:20 PM ET.
The Cubs will send Clay Holmes (4-5, 2.86 ERA) to the mound, pitting him against Matthew Liberatore (5-9, 5.15 ERA) for the Cardinals.
Dimers' proven MLB model projects the Cubs as the most likely winner in this Cardinals vs. Cubs prediction.
This article offers a closer look at Friday's matchup, including best bets and picks.
Cardinals vs. Cubs prediction: Who will win and cover?
Our leading predictive model gives the Cubs a 62.3% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 56.2% chance of covering the run line, while the 8.5-run over/under has a 50.4% chance of staying under,.
Cardinals vs. Cubs odds [8/14/2026]
We have researched the best MLB odds in America for this game, which are listed here:
- Run Line: Cardinals +1.5 (-127) / Cubs -1.5 (+125)
- Moneyline: Cardinals +170, Cubs -174
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Cubs picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Cardinals +1.5 @ -127 via DraftKings
- Moneyline: Cardinals @ +170 via Novig
- Total: Over 8.5 @ +120 via Novig
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Cubs game-day updates and essential details
Friday's MLB matchup between the Cubs and Cardinals at Wrigley Field is scheduled to commence at 2:20 PM ET.
- Who: St. Louis Cardinals vs. Chicago Cubs
- Date: Friday, August 14, 2026
- Time: 2:20 PM ET/11:20AM PT
- Venue: Wrigley Field
Conclusion
We predict the Cubs, with a 62.3% win probability, will likely beat the Cardinals in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
