Aug 28, 2026
Diamondbacks vs. Giants prediction: Arizona favored to win Friday's MLB matchup [8/28/2026]
Read Article Pirates vs. Cardinals prediction: Pittsburgh favored to win Friday's MLB matchup [8/28/2026]
Updated: | First published:
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Written by Dave Garofolo, Content Producer
Get Pittsburgh Pirates vs St. Louis Cardinals predictions for MLB Friday.
MLB action continues on Friday at 8:15 PM ET as the Pittsburgh Pirates square off with the St. Louis Cardinals at Busch Stadium.
The Cardinals will send Quinn Mathews (0-2, 6.43 ERA) to the mound, while the Pirates have opted for Jared Jones (2-5, 4.76 ERA).
Dimers' advanced MLB model gives the Pirates a slight edge with a 52.0% win probability over the Cardinals.
This article offers a complete Pirates vs. Cardinals prediction, including best bets and picks.
Pirates vs. Cardinals prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the outcome of Friday's MLB matchup between the Pirates and Cardinals, forming part of our MLB predictions coverage.
Our famous predictive model gives the Pirates a 52.0% chance of defeating the Cardinals.
According to our model, the Cardinals (+1.5) have a 60.8% chance of covering the run line, while the over/under total of 7.5 runs has a 53.9% chance of going over.
Pirates vs. Cardinals odds [8/28/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: Pirates -1.5 (+155) / Cardinals +1.5 (-156)
- Moneyline: Pirates -108, Cardinals +106
All odds are correct at the time of publication and are subject to change.
Pirates vs. Cardinals picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Pirates -1.5 @ +155 via DraftKings
- Moneyline: Pirates @ -108 via Novig
- Total: Over 7.5 @ +102 via BetRivers
According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Pirates vs. Cardinals game-day updates and essential details
Friday's MLB matchup between the Cardinals and Pirates at Busch Stadium is scheduled to commence at 8:15 PM ET.
- Who: Pittsburgh Pirates vs. St. Louis Cardinals
- Date: Friday, August 28, 2026
- Time: 8:15 PM ET/5:15PM PT
- Venue: Busch Stadium
Conclusion
We predict the Pirates, with a 52.0% win probability, will likely beat the Cardinals in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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