Aug 22, 2026
Today’s top 10 most likely home run hitters, plus +368 pick for Saturday [8/22/2026]
Read Article Reds vs. Diamondbacks prediction: Why Arizona is favored to win Saturday's MLB matchup [8/22/2026]
Updated: | First published:
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Written by Dave Garofolo, Content Producer
Get Cincinnati Reds vs Arizona Diamondbacks predictions for MLB Saturday.
MLB action continues on Saturday at 8:10 PM ET as the Cincinnati Reds square off with the Arizona Diamondbacks at Chase Field.
The Diamondbacks will start Michael Soroka (8-3, 2.94 ERA), up against Rhett Lowder (4-8, 5.17 ERA) for the Reds.
Dimers' advanced MLB model projects the Diamondbacks as the most likely winner in this Reds vs. Diamondbacks prediction.
This article offers a closer look at Saturday's matchup, including best bets and picks.
Reds vs. Diamondbacks prediction: Who will win and cover?
Using powerful machine learning and statistical analysis, we have simulated the outcome of Saturday's MLB matchup between the Reds and Diamondbacks, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Diamondbacks a 62.0% chance of beating the Reds.
According to our model, the Reds (+1.5) have a 55.5% chance of covering the run line, while the 8.5-run over/under has a 57.1% chance of going over.
Reds vs. Diamondbacks odds [8/22/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: Reds +1.5 (-133) / Diamondbacks -1.5 (+132)
- Moneyline: Reds +163, Diamondbacks -163
All odds are correct at the time of publication and are subject to change.
Reds vs. Diamondbacks picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Diamondbacks -1.5 @ +132 via DraftKings
- Moneyline: Reds @ +163 via DraftKings
- Total: Over 8.5 @ +117 via Polymarket
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Reds vs. Diamondbacks game-day updates and essential details
Saturday's MLB action between the Diamondbacks and Reds at Chase Field is scheduled to begin at 8:10 PM ET.
- Who: Cincinnati Reds vs. Arizona Diamondbacks
- Date: Saturday, August 22, 2026
- Time: 8:10 PM ET/5:10PM PT
- Venue: Chase Field
Conclusion
We predict the Diamondbacks, with a 62.0% win probability, will likely beat the Reds in Saturday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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