Aug 21, 2026
MLB picks today: Friday's MLB best bets include Angels vs. Rangers play [8/21/2026]
Read Article Reds vs. Diamondbacks prediction: Why Arizona is favored to win Friday's MLB matchup [8/21/2026]
Updated: | First published:
Add Dimers on Google 
Written by Dave Garofolo, Content Producer
Get Cincinnati Reds vs Arizona Diamondbacks predictions for MLB Friday.
The Arizona Diamondbacks will square off with the Cincinnati Reds in MLB action at Chase Field on Friday, commencing at 9:40 PM ET.
The Diamondbacks will send Eduardo Rodriguez (12-4, 2.71 ERA) to the mound, while the Reds will counter with Nick Lodolo (3-2, 4.52 ERA).
Dimers' advanced MLB model projects the Diamondbacks as the most likely winner in this Reds vs. Diamondbacks prediction.
This article offers further insights into Friday's matchup, including best bets and picks.
Reds vs. Diamondbacks prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Friday's MLB game between the Reds and Diamondbacks, forming part of our MLB predictions coverage.
Our leading predictive model currently gives the Diamondbacks a 57.5% chance of defeating the Reds.
According to our model, the Reds (+1.5) have a 59.1% chance of covering the run line, while the over/under total of 8.5 runs has a 59.0% chance of going over.
Reds vs. Diamondbacks odds [8/21/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: Reds +1.5 (-153) / Diamondbacks -1.5 (+150)
- Moneyline: Reds +135, Diamondbacks -138
All odds are correct at the time of publication and are subject to change.
Reds vs. Diamondbacks picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Diamondbacks -1.5 @ +150 via DraftKings
- Moneyline: Reds @ +135 via Bet365
- Total: Over 8.5 @ +104 via Novig
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Reds vs. Diamondbacks game-day updates and essential details
Friday's MLB matchup between the Diamondbacks and Reds at Chase Field is scheduled to begin at 9:40 PM ET.
- Who: Cincinnati Reds vs. Arizona Diamondbacks
- Date: Friday, August 21, 2026
- Time: 9:40 PM ET/6:40PM PT
- Venue: Chase Field
Conclusion
We predict the Diamondbacks, with a 57.5% win probability, will likely beat the Reds in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Continue reading with Dimers Pro
Join now to unlock this article and get full access to our predictions and betting tools. Cancel anytime.
EARLY BIRD PRICE
6 months of Dimers Pro
Full football season covered
NFL + College Football
One payment. Renews in 6 months.
Your Pro access is locked in for 6 months. Cancel or pause anytime.
Access to every sport, all season long.
Everything in Dimers Pro - not just football
Already a Pro member? Log in
New here? See everything Pro includes
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
Advertiser disclosure
