White Sox vs. Cardinals prediction: White Sox favored to win Sunday's MLB matchup [9/13/2026]

The St. Louis Cardinals will face the Chicago White Sox, in what is expected to be a tight MLB game, at Busch Stadium on Sunday, commencing at 2:15 PM ET.

Michael McGreevy (6-9, 3.92 ERA) will be on the bump for the Cardinals, while the White Sox are going with David Sandlin (2-1, 6.93 ERA).

Dimers' proven MLB model gives the White Sox a slight edge with a 50.2% win probability over the Cardinals.

This article offers a complete White Sox vs. Cardinals prediction, including best bets and picks.

White Sox vs. Cardinals prediction and odds

Using innovative machine learning and data analysis, we have re-simulated the outcome of Sunday's MLB matchup between the White Sox and Cardinals, forming part of our MLB predictions coverage.

Our leading predictive model gives the White Sox a 50.2% chance of defeating the Cardinals. According to our model, the Cardinals (+1.5) have a 61.5% chance of covering the run line, while the 8.5-run over/under has a 53.6% chance of going over.

Latest betting odds

We have sourced the best MLB odds in America for this game, which are listed here:

• Run Line: White Sox -1.5 (+150) / Cardinals +1.5 (-147)
• Moneyline: White Sox -108, Cardinals +110
• Total: Over/Under 8.5 (-113/+113)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Run line: Cardinals +1.5 @ 60¢ via Novig
• Moneyline: Cardinals @ +110 via bet365
• Total: Over 8.5 @ 53¢ via Polymarket

According to our MLB best bets, the top play to make on this game is Cardinals to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & first pitch details

Sunday's MLB game between the Cardinals and White Sox at Busch Stadium is scheduled to start at 2:15 PM ET.

• Who: Chicago White Sox vs. St. Louis Cardinals
• Date: Sunday, September 13, 2026
• Time: 2:15 PM ET/11:15AM PT
• Venue: Busch Stadium

Conclusion

We predict the White Sox, with a 50.2% win probability, will likely beat the Cardinals in Sunday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary MLB prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.