Aug 25, 2026
Astros vs. Yankees prediction: Yankees favored to win Tuesday's MLB matchup [8/25/2026]
Read Article Cubs vs. Diamondbacks prediction: Why Arizona is favored to win Tuesday's MLB matchup [8/25/2026]
Updated: | First published:
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Written by Dave Garofolo, Content Producer
Get Chicago Cubs vs Arizona Diamondbacks predictions for MLB Tuesday.
The Arizona Diamondbacks will take on the Chicago Cubs, in what is expected to be a close MLB game, at Chase Field on Tuesday, commencing at 9:40 PM ET.
The Diamondbacks will have Brandon Pfaadt (7-1, 3.39 ERA) as their starting pitcher, pitting him against Clay Holmes (5-6, 2.49 ERA) for the Cubs.
Dimers' proven MLB model gives the Diamondbacks a slight edge with a 51.2% win probability over the Cubs.
This article offers a complete Cubs vs. Diamondbacks prediction, including best bets and picks.
Cubs vs. Diamondbacks prediction: Who will win and cover?
Using powerful machine learning and data analysis, we have simulated the result of Tuesday's MLB game between the Cubs and Diamondbacks, forming part of our MLB predictions coverage.
Our independent predictive model gives the Diamondbacks a 51.2% chance of beating the Cubs.
According to our model, the Diamondbacks (+1.5) have a 62.2% chance of covering the run line, while the over/under total of 8.5 runs has a 58.8% chance of going over.
Cubs vs. Diamondbacks odds [8/25/2026]
We have researched the best MLB odds in America for this game, which are listed here:
- Run Line: Cubs -1.5 (+160) / Diamondbacks +1.5 (-163)
- Moneyline: Cubs -102, Diamondbacks +104
All odds are correct at the time of publication and are subject to change.
Cubs vs. Diamondbacks picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Diamondbacks +1.5 @ -163 via DraftKings
- Moneyline: Diamondbacks @ +104 via Polymarket
- Total: Over 8.5 @ +102 via Novig
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cubs vs. Diamondbacks game-day updates and essential details
Tuesday's MLB game between the Diamondbacks and Cubs at Chase Field is scheduled to start at 9:40 PM ET.
- Who: Chicago Cubs vs. Arizona Diamondbacks
- Date: Tuesday, August 25, 2026
- Time: 9:40 PM ET/6:40PM PT
- Venue: Chase Field
Conclusion
We predict the Diamondbacks, with a 51.2% win probability, will likely beat the Cubs in Tuesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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