Aug 26, 2026
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Read Article Orioles vs. Cardinals prediction: St. Louis favored to win Wednesday's MLB matchup [8/26/2026]
Updated: | First published:
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Written by Dave Garofolo, Content Producer
Get Baltimore Orioles vs St. Louis Cardinals predictions for MLB Wednesday.
The St. Louis Cardinals will take on the Baltimore Orioles, in what is expected to be a tight MLB game, at Busch Stadium on Wednesday, commencing at 7:45 PM ET.
Michael McGreevy (5-9, 3.54 ERA) will be the starting pitcher for the Cardinals, while the Orioles have opted for Kyle Bradish (7-12, 3.70 ERA).
Dimers' advanced MLB model gives the Cardinals a slight edge with a 50.5% win probability over the Orioles.
This article offers a complete Orioles vs. Cardinals prediction, including best bets and picks.
Orioles vs. Cardinals prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Orioles and Cardinals, forming part of our MLB predictions coverage.
Our famous predictive model gives the Cardinals a 50.5% chance of defeating the Orioles.
According to our model, the Cardinals (+1.5) have a 62.7% chance of covering the run line, while the 8.5-run over/under has a 52.8% chance of going over.
Orioles vs. Cardinals odds [8/26/2026]
We have researched the best MLB odds in America for this game, which are listed here:
- Run Line: Orioles -1.5 (+165) / Cardinals +1.5 (-170)
- Moneyline: Orioles +100, Cardinals +100
All odds are correct at the time of publication and are subject to change.
Orioles vs. Cardinals picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Cardinals +1.5 @ -170 via DraftKings
- Moneyline: Cardinals @ +100 via Novig
- Total: Over 8.5 @ +104 via Novig
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Orioles vs. Cardinals game-day updates and essential details
Wednesday's MLB matchup between the Cardinals and Orioles at Busch Stadium is scheduled to begin at 7:45 PM ET.
- Who: Baltimore Orioles vs. St. Louis Cardinals
- Date: Wednesday, August 26, 2026
- Time: 7:45 PM ET/4:45PM PT
- Venue: Busch Stadium
Conclusion
We predict the Cardinals, with a 50.5% win probability, will likely beat the Orioles in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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