Aug 25, 2026
Astros vs. Yankees prediction: Yankees favored to win Tuesday's MLB matchup [8/25/2026]
Read Article Orioles vs. Cardinals prediction: St. Louis favored to win Tuesday's MLB matchup [8/25/2026]
Updated: | First published:
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Written by Dave Garofolo, Content Producer
Get Baltimore Orioles vs St. Louis Cardinals predictions for MLB Tuesday.
MLB action continues on Tuesday at 7:45 PM ET as the Baltimore Orioles take on the St. Louis Cardinals at Busch Stadium.
Matthew Liberatore (5-11, 5.04 ERA) will start on the mound for the Cardinals, while the Orioles have opted for Chris Bassitt (4-4, 5.08 ERA).
Dimers' proven MLB model gives the Cardinals a slight edge with a 54.8% win probability over the Orioles.
This article offers a complete Orioles vs. Cardinals prediction, including best bets and picks.
Orioles vs. Cardinals prediction: Who will win and cover?
Using innovative machine learning and statistical analysis, we have simulated the result of Tuesday's MLB matchup between the Orioles and Cardinals, forming part of our MLB predictions coverage.
Our famous predictive model gives the Cardinals a 54.8% chance of beating the Orioles.
According to our model, the Orioles (+1.5) have a 62.0% chance of covering the run line, while the 8.5-run over/under has a 55.6% chance of going over.
Orioles vs. Cardinals odds [8/25/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: Orioles +1.5 (-178) / Cardinals -1.5 (+170)
- Moneyline: Orioles +117, Cardinals -122
All odds are correct at the time of publication and are subject to change.
Orioles vs. Cardinals picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Cardinals -1.5 @ +170 via DraftKings
- Moneyline: Cardinals @ -122 via Novig
- Total: Over 8.5 @ -106 via Novig
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Orioles vs. Cardinals game-day updates and essential details
Tuesday's MLB game between the Cardinals and Orioles at Busch Stadium is scheduled to start at 7:45 PM ET.
- Who: Baltimore Orioles vs. St. Louis Cardinals
- Date: Tuesday, August 25, 2026
- Time: 7:45 PM ET/4:45PM PT
- Venue: Busch Stadium
Conclusion
We predict the Cardinals, with a 54.8% win probability, will likely beat the Orioles in Tuesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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