Missouri vs. Kansas prediction favors Missouri to win in college football Week 2 [2026]

Kansas will take on Missouri in Week 2 college football action at David Booth Kansas Memorial Stadium on Friday, starting at 8:00 PM ET.

Dimers' proven college football model projects Missouri as the most likely winner in this Missouri vs. Kansas prediction.

This article offers an expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.

Missouri vs. Kansas prediction and odds

Using trusted machine learning and statistical analysis, we have re-simulated the result of Missouri vs. Kansas, forming part of our college football predictions coverage.

Our independent predictive model currently gives Missouri a 63.8% chance of beating Kansas. Our predicted final score has Missouri winning 28-24. According to our model, Kansas (+4.5) has a 52.1% chance of covering the spread, while the over/under total of 51.5 points has a 52.7% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Missouri -4.5 (-105) / Kansas +4.5 (-109)
• Moneyline: Missouri -190, Kansas +168
• Total: Over/Under 51.5 (-110/-107)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Kansas +4.5 @ -109 via Caesars
• Moneyline: Kansas @ +168 via FanDuel
• Total: Over 51.5 @ -110 via bet365

According to our college football best bets, the top play to make on this game is Over 51.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Friday's college football game between Kansas and Missouri at David Booth Kansas Memorial Stadium is scheduled to start at 8:00 PM ET.

• Who: Missouri vs. Kansas
• Date: Friday, September 11, 2026
• Time: 8:00 PM ET/5:00PM PT
• Venue: David Booth Kansas Memorial Stadium

College football Week 2 promos

Make the most of Dimers' Missouri vs. Kansas predictions by exploring the Bet365 Sportsbook offer below:

Conclusion

We predict Missouri, with a 63.8% win probability, will likely beat Kansas in Friday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.