Sep 6, 2026
South Carolina State vs. Florida A&M prediction: South Carolina State favored to win in college football Week 1 [2026]
Read Article Louisville vs. Ole Miss prediction: Why Mississippi is favored to win in college football Week 1 [2026]
Updated: | First published:
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Written by Mac Douglass, Senior Editor
Dimers' simulation model projects a 63.2% win probability for Mississippi at Nissan Stadium.
Mississippi will face Louisville in Week 1 college football action at Nissan Stadium on Sunday, starting at 7:30 PM ET.
Dimers' proven college football model projects Mississippi as the most likely winner in this Louisville vs. Ole Miss prediction.
This article offers a closer look at Sunday's matchup, including an expanded look at the predicted score, best bets and picks, backed by the same system that has dominated college football and NFL betting markets across multiple seasons.
Louisville vs. Ole Miss prediction and odds
Using innovative machine learning and data, we have simulated the result of Louisville vs. Ole Miss, forming part of our college football predictions coverage.
Our leading predictive model gives Mississippi a 63.2% chance of defeating Louisville. Our predicted final score has Mississippi winning 28-23.
According to our model, Louisville (+6.5) has a 52.6% chance of covering the spread, while the 55.5-point over/under has a 57.5% chance of staying under.
Latest betting odds
We have sourced the best college football odds in America for this game, which are listed here:
- Spread: Louisville +6.5 (+100) / Ole Miss -6.5 (-114)
- Moneyline: Louisville +210, Ole Miss -250
- Total: Over/Under 55.5 (-110/-110)
All odds are correct at the time of publication and are subject to change.
Model picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Spread: Louisville +6.5 @ +100 via Fanatics
- Moneyline: Louisville @ +210 via bet365
- Total: Under 55.5 @ -110 via bet365
According to our college football best bets, the top play to make on this game is Under 55.5 total points.
These picks are based on our probabilities matched against the implied probabilities from the current available odds.
Game info & kickoff details
Sunday's college football game between Ole Miss and Louisville at Nissan Stadium is scheduled to start at 7:30 PM ET.
- Who: Louisville vs. Mississippi
- Date: Sunday, September 6, 2026
- Time: 7:30 PM ET/4:30PM PT
- Venue: Nissan Stadium
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Make the most of Dimers' Louisville vs. Mississippi predictions by exploring the Underdog Fantasy offfer below
Conclusion
We predict Mississippi, with a 63.2% win probability, will likely beat Louisville in Sunday's college football matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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