Louisiana-Monroe vs. Mississippi State prediction: Why Mississippi State is favored to win in college football Week 1 [2026]

Using trusted machine learning and statistical analysis, we have simulated the outcome of Louisiana-Monroe vs. Mississippi State, forming part of our college football predictions coverage.

Our leading predictive model gives Mississippi State a 96.5% chance of beating Louisiana-Monroe. Our predicted final score has Mississippi State winning 40-12.

According to our model, Mississippi State (-28) has a 52.5% chance of covering the spread, while the over/under total of 55.5 points has a 55.9% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Louisiana-Monroe +28 (-105) / Mississippi State -28 (-115)
• Moneyline: Louisiana-Monroe +2000, Mississippi State -4000
• Total: Over/Under 55.5 (-115/-105)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Mississippi State -28 @ -115 via ESPN BET
• Moneyline: Mississippi State @ -4000 via DraftKings
• Total: Under 55.5 @ -105 via BetMGM

According to our college football best bets, the top play to make on this game is Under 55.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Mississippi State and Louisiana-Monroe at Davis Wade Stadium at Scott Field is scheduled to commence at 7:30 PM ET.

• Who: Louisiana-Monroe vs. Mississippi State
• Date: Saturday, September 5, 2026
• Time: 7:30 PM ET/4:30PM PT
• Venue: Davis Wade Stadium at Scott Field

College football Week 1 promos

Make the most of Dimers' Louisiana-Monroe vs. Mississippi State predictions by exploring the Underdog Fantasy offfer below

Conclusion

We predict Mississippi State, with a 96.5% win probability, will likely beat Louisiana-Monroe in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.