Holy Cross vs. Miami Ohio prediction: Why Miami Ohio is favored to win in college football Week 2 [2026]

Using powerful machine learning and data, we have re-simulated the outcome of Holy Cross vs. Miami Ohio, forming part of our college football predictions coverage.

Our independent predictive model gives Miami Ohio a 97.8% chance of defeating Holy Cross. Our predicted final score has Miami Ohio winning 39-10. According to our model, Holy Cross (+31.5) has a 56.9% chance of covering the spread, while the 47.5-point over/under has a 56.4% chance of going over.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Holy Cross +31.5 (-118) / Miami Ohio -31.5 (-104)
• Moneyline: Holy Cross +2500, Miami Ohio -6502
• Total: Over/Under 47.5 (-105/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Holy Cross +31.5 @ -118 via FanDuel
• Moneyline: Miami Ohio @ -6502 via DraftKings
• Total: Over 47.5 @ -105 via DraftKings

According to our best college football bets, the top play to make on this game is Over 47.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Miami Ohio and Holy Cross at Fred C. Yager Stadium is scheduled to begin at 1:00 PM ET.

• Who: Holy Cross vs. Miami Ohio
• Date: Saturday, September 12, 2026
• Time: 1:00 PM ET/10:00AM PT
• Venue: Fred C. Yager Stadium

College football Week 2 promos

Make the most of Dimers' Holy Cross vs. Miami Ohio predictions by exploring the Underdog Fantasy offfer below

Conclusion

We predict Miami Ohio, with a 97.8% win probability, will likely beat Holy Cross in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.