Seahawks vs. Cardinals: NFL Week 2 Prediction, Picks & Odds

Dimers' Seahawks vs. Cardinals prediction for Sunday, September 20, 2026. Win probabilities, projected final score, current odds, and picks from our NFL machine learning models.
NFL
Add this game to My Favorites
Add this game to My Favorites
NFL sport icon
NFL
Seahawks
Predicted score
24
:
19
State Farm Stadium
Cardinals
State Farm Stadium
Pre-Game Probabilities Last Update:

Spread

Seahawks -4.5
Spread
  • Seahawks
    51.6%
    NovigNovig
  • Cardinals
    48.4%
    NovigNovig

Seahawks vs. Cardinals: Detailed Breakdown

Matchup overview: NFL Week 2

  • Teams: Seattle Seahawks vs. Arizona Cardinals
  • Date: Sunday, September 20, 2026
  • Time: 4:25PM ET
  • Venue: State Farm Stadium

Current betting odds

  • Spread: Seahawks (-4.5, +100), Cardinals (+4.5, -108)
  • Moneyline: Seahawks -203, Cardinals +208
  • Total (Over/Under): 40.5 points (+100/-103)

Dimers’ win probabilities

  • Seahawks: 66.6%
  • Cardinals: 33.4%

These probabilities come from two machine learning models that assess more than 100 data points for each NFL matchup, combining their outputs to project all our major betting markets.

Projected final score

Our predicted final score for this NFL matchup is Seahawks 23-18 Cardinals.

This prediction draws on each team's scoring trends and player stats, weighed across both of our data models.

Our Prediction: Who Wins?

The numbers give the Seahawks a win probability of 66.6%, while the Cardinals have a win probability of 33.4%.

Summary

The Seahawks face off against the Cardinals in the NFL at State Farm Stadium on Sunday, September 20, 2026.

Our Seahawks vs. Cardinals predictions, built on real-time data and matchup-specific modeling, help guide your decisions.. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

For further insights, explore our expert NFL predictions and the best NFL bets today, while our in-depth analysis includes NFL props, NFL futures, NFL odds, and the latest NFL news.