RECOMMENDED
Deposit $10, Get a $20 Trading Bonus!
T&Cs apply.
Cardinals vs. Cubs Prediction, Picks and Odds
Our detailed prediction and analysis for the Cardinals vs. Cubs MLB game on September 27, 2025 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
FINAL
MLB
FINAL
MLB
Cardinals
Michael McGreevy 8-3, 4.35 ERA
3
7
Sep 27, 2:20 PM ET Wrigley Field
Cubs
Jameson Taillon 10-7, 3.78 ERA
Sep 27, 2:20 PM ET Wrigley Field
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | R | H | E | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cardinals | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 3 | 7 | 0 |
Cubs | 1 | 0 | 0 | 0 | 2 | 1 | 1 | 2 | X | 7 | 10 | 0 |
Live Probabilities
Moneyline
Over / Under
Run Line
- Cardinals
- Cubs
Win Probability
Last At Bat
Outs
Nathan Church strikes out swinging.
Quick Box Score
Hitting
Pitching
| No. | Player | Pos | AB | R | H | RBI | HR | BB | SO | AVG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | L. Nootbaar | LF | 3 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0.250 |
| 2 | I. Herrera | DH | 4 | 0 | 1 | 0 | 0 | 0 | 2 | 0.25 | 0.500 |
| 3 | A. Burleson | 1B | 4 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0.000 |
| 4 | N. Arenado | 3B | 4 | 1 | 2 | 1 | 1 | 0 | 0 | 0.5 | 1.750 |
| 5 | N. Gorman | 2B | 4 | 0 | 1 | 0 | 0 | 0 | 3 | 0.25 | 0.500 |
| 6 | T. Saggese | SS | 4 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0.000 |
| 7 | J. Crooks | C | 4 | 1 | 2 | 0 | 0 | 0 | 1 | 0.5 | 1.000 |
| 8 | J. Walker | RF | 2 | 1 | 1 | 2 | 1 | 2 | 0 | 0.5 | 2.750 |
| 9 | N. Church | CF | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0.000 |
| No. | Player | Pos | AB | R | H | RBI | HR | BB | SO | AVG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M. Busch | 1B | 4 | 2 | 4 | 4 | 2 | 0 | 0 | 1 | 4.250 |
| 2 | N. Hoerner | 2B | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.000 |
| 3 | I. Happ | LF | 4 | 0 | 1 | 0 | 0 | 0 | 3 | 0.25 | 0.500 |
| 4 | K. Tucker | DH | 4 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0.000 |
| 5 | S. Suzuki | RF | 2 | 2 | 1 | 1 | 1 | 2 | 0 | 0.5 | 2.750 |
| 6 | C. Kelly | C | 4 | 0 | 1 | 0 | 0 | 0 | 1 | 0.25 | 0.500 |
| 7 | P. Crow-Armstrong | CF | 4 | 1 | 2 | 2 | 1 | 0 | 1 | 0.5 | 1.750 |
| 8 | D. Swanson | SS | 3 | 0 | 1 | 0 | 0 | 1 | 0 | 0.333 | 1.167 |
| 9 | M. Shaw | 3B | 3 | 2 | 0 | 0 | 0 | 1 | 2 | 0 | 0.250 |
Featured offers
Swipe across to view more offers
FEATURED
New DraftKings Customers: Spend $5+ Get $150 in Bonus Bets *Paid Within 14 Days
T&Cs apply.
NEW PLAYERS
Bet $5, Get $150 in Bonus Bets if your bet wins!
T&Cs apply.
TRENDING
Bet $10 Get $150 in Bonus Bets
T&Cs apply.
NEW
Trade $10, Get $20 with Code DIMERS
T&Cs apply.
HOTTEST
$1,000 First Bet Reset Paid in Bonus Bets!
T&Cs apply.
NEW PLAYERS
Get $350 in Bonus Bets Guaranteed - When You Bet $5 for 7 Days!
T&Cs apply.
LIMITED-TIME
Register with code DIMERS150 to unlock $150 in bonus bets by winning your first $10 bet
T&Cs apply.
RECOMMENDED
Code DIMERS: Trade $10, Get $10
T&Cs apply.
NEW PLAYERS
Get Up To $250 Back in Bonus Bets If Your First Bet Loses
T&Cs apply.
Cardinals vs. Cubs: Detailed Breakdown
Matchup Overview
- Teams: Cardinals vs. Cubs
- Date: Saturday, September 27, 2025
- Time: 2:20 PM ET
- Venue: Wrigley Field
Current Betting Odds
- Spread: Cubs favored at -1.5
- Total (Over/Under): 9.5
- Moneyline Odds: Cardinals +155, Cubs -178
Dimers' Win Probabilities
- Cardinals: 38%
- Cubs: 62%
Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.
Our Prediction: Who Wins?
After extensive simulations, our model gives the Cardinals a win probability of 38%, while the Cubs have a win probability of 62%. Discover the best spread, over/under, and moneyline odds for the game on this page.
Summary
According to our analysis, the Cubs are more likely to beat the Cardinals in the MLB game at Wrigley Field on Saturday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.
Our Cardinals vs. Cubs predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.
For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.
For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.