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Cardinals vs. Cubs Prediction, Picks and Odds

Our detailed prediction and analysis for the Cardinals vs. Cubs MLB game on September 26, 2025 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
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MLB
Cardinals
1
12
Sep 26, 6:20PM Wrigley Field
Cubs
Sep 26, 6:20PM Wrigley Field
In-Play ProbabilitiesIn-Play
Game PredictionsPre-Game
Dimers Pro Best Bets
1 2 3 4 5 6 7 8 9 RHE
Cardinals
0 0 0 0 0 0 1 0 0 1 5 0
Cubs
1 0 0 2 1 0 7 1 X 12 12 0
Live Probabilities
Moneyline
Over / Under
Run Line
Cardinals STL
Win %
0%
100%
Cubs CHC
Win Probability
Last At Bat
Outs
Pedro Pagés pops out to shallow center field to Dansby Swanson.
Quick Box Score
Hitting
Pitching
Cardinals Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 L. Nootbaar LF300001100.250
2 J. Crooks DH100000000.000
3 Y. Pozo 1B100000100.000
4 J. Fermín 2B100000000.000
5 N. Gorman 3B41200020.51.250
6 T. Saggese SS40100020.250.500
7 P. Pagés C400000200.000
8 J. Walker RF30110010.3330.666
9 V. Scott CF300000200.000
Cubs Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 M. Ballesteros 1B111000012.000
2 N. Hoerner 2B52211010.41.400
3 K. Alcántara LF101100012.000
4 K. Tucker DH42100100.250.650
5 S. Suzuki RF41141010.251.250
6 P. Crow-Armstrong CF31121010.3331.833
7 D. Swanson SS310001100.250
8 R. McGuire C400000100.000
9 M. Shaw 3B41110010.251.000

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Cardinals vs. Cubs: Detailed Breakdown

Matchup Overview

  • Teams: Cardinals vs. Cubs
  • Date: Friday, September 26, 2025
  • Time: 2:20 PM ET
  • Venue: Wrigley Field

Current Betting Odds

  • Spread: Cubs favored at -1.5
  • Total (Over/Under): 9
  • Moneyline Odds: Cardinals +176, Cubs -181

Dimers' Win Probabilities

  • Cardinals: 38%
  • Cubs: 62%

Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Cardinals a win probability of 38%, while the Cubs have a win probability of 62%. Discover the best spread, over/under, and moneyline odds for the game on this page.

Summary

According to our analysis, the Cubs are more likely to beat the Cardinals in the MLB game at Wrigley Field on Friday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Cardinals vs. Cubs predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.

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