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Cubs vs. Reds Prediction, Picks and Odds
Our detailed prediction and analysis for the Cubs vs. Reds MLB game on September 21, 2025 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
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MLB
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MLB
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Sep 21, 5:40 PM Great American Ball Park
Sep 21, 5:40 PM Great American Ball Park
In-Play ProbabilitiesIn-Play
Game PredictionsPre-Game
Pro Bets
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | R | H | E | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cubs | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0 |
Reds | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | X | 1 | 5 | 0 |
Live Probabilities
Moneyline
Over / Under
Run Line
Win %
0%
100%
Win Probability
Last At Bat
Outs
Pete Crow-Armstrong called out on strikes.
Quick Box Score
Hitting
Pitching
| No. | Player | Pos | AB | R | H | RBI | HR | BB | SO | AVG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | N. Hoerner | 2B | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.000 |
| 2 | I. Happ | LF | 4 | 0 | 1 | 0 | 0 | 0 | 2 | 0.25 | 0.500 |
| 3 | S. Suzuki | RF | 4 | 0 | 1 | 0 | 0 | 0 | 1 | 0.25 | 0.500 |
| 4 | C. Kelly | C | 3 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0.250 |
| 5 | M. Ballesteros | DH | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0.500 |
| 6 | D. Swanson | SS | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0.25 | 0.500 |
| 7 | W. Castro | PH | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0.000 |
| 8 | M. Busch | 1B | 3 | 0 | 1 | 0 | 0 | 1 | 0 | 0.333 | 0.833 |
| 9 | P. Crow-Armstrong | CF | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0.000 |
| No. | Player | Pos | AB | R | H | RBI | HR | BB | SO | AVG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | T. Friedl | CF | 4 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0.000 |
| 2 | G. Lux | DH | 4 | 0 | 2 | 1 | 0 | 0 | 0 | 0.5 | 1.250 |
| 3 | N. Marte | RF | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0.333 | 0.666 |
| 4 | S. Steer | 1B | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0.000 |
| 5 | W. Benson | LF | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.000 |
| 6 | E. De La Cruz | SS | 3 | 0 | 1 | 0 | 0 | 0 | 1 | 0.333 | 0.666 |
| 7 | K. Hayes | 3B | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0.000 |
| 8 | J. Trevino | C | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.000 |
| 9 | M. McLain | 2B | 3 | 1 | 1 | 0 | 0 | 0 | 1 | 0.333 | 1.000 |
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Cubs vs. Reds: Detailed Breakdown
Matchup Overview
- Teams: Cubs vs. Reds
- Date: Sunday, September 21, 2025
- Time: 1:40 PM ET
- Venue: Great American Ball Park
Current Betting Odds
- Spread: Reds favored at -1.5
- Total (Over/Under): 9
- Moneyline Odds: Cubs +106, Reds -110
Dimers' Win Probabilities
- Cubs: 49%
- Reds: 51%
Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.
Our Prediction: Who Wins?
After extensive simulations, our model gives the Cubs a win probability of 49%, while the Reds have a win probability of 51%. Discover the best spread, over/under, and moneyline odds for the game on this page.
Summary
According to our analysis, the Reds are more likely to beat the Cubs in the MLB game at Great American Ball Park on Sunday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.
Our Cubs vs. Reds predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.
For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.
