Cubs vs. Pirates Prediction, Picks and Odds

Our detailed prediction and analysis for the Cubs vs. Pirates MLB game on September 17, 2025 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
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MLB sport icon
MLB
Cubs
8
4
Sep 17, 4:35 PM PNC Park
Pirates
Sep 17, 4:35 PM PNC Park
In-Play ProbabilitiesIn-Play
Game PredictionsPre-Game
Pro Bets
1 2 3 4 5 6 7 8 9 RHE
Cubs
4 0 0 0 0 3 0 1 0 8 10 1
Pirates
3 1 0 0 0 0 0 0 0 4 10 3
Live Probabilities
Moneyline
Over / Under
Run Line
Cubs CHC
Win %
100%
0%
Pirates PIT
Win Probability
Baseball infield diamond diagram
Last At Bat
Outs
Oneil Cruz flies out to left field to Ian Happ.
Quick Box Score
Hitting
Pitching
Cubs Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 M. Busch 1B210102100.400
2 N. Hoerner 2B43200100.51.100
3 I. Happ LF41231100.51.850
4 J. Turner DH202200012.000
5 K. Alcántara RF100000100.000
6 P. Crow-Armstrong CF50100010.20.600
7 D. Swanson SS41100120.250.650
8 R. McGuire C50100000.20.400
9 M. Shaw 3B310002000.400
Pirates Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 J. Triolo SS50200010.40.800
2 N. Gonzales 2B40200000.51.100
3 T. Pham LF410001000.200
4 A. McCutchen DH41110120.250.650
5 J. Bart C41131020.251.400
6 O. Cruz CF200000000.000
7 N. Yorke 3B40100010.250.500
8 R. Flores 1B30100110.3331.167
9 J. Suwinski RF200000200.000

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Cubs vs. Pirates: Detailed Breakdown

Matchup Overview

  • Teams: Cubs vs. Pirates
  • Date: Wednesday, September 17, 2025
  • Time: 12:35 PM ET
  • Venue: PNC Park

Current Betting Odds

  • Spread: Cubs favored at -1.5
  • Total (Over/Under): 10.5
  • Moneyline Odds: Cubs -140, Pirates +400

Dimers' Win Probabilities

  • Cubs: 55%
  • Pirates: 45%

Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Cubs a win probability of 55%, while the Pirates have a win probability of 45%. Discover the best spread, over/under, and moneyline odds for the game on this page.

Summary

According to our analysis, the Cubs are more likely to beat the Pirates in the MLB game at PNC Park on Wednesday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Cubs vs. Pirates predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.