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Orioles vs. Guardians Prediction, Picks and Odds

Our detailed prediction and analysis for the Orioles vs. Guardians MLB game on July 22, 2025 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
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MLB
Orioles
3
6
Jul 22, 10:40PM Progressive Field
Guardians
Jul 22, 10:40PM Progressive Field
In-Play ProbabilitiesIn-Play
Game PredictionsPre-Game
Dimers Pro Best Bets
1 2 3 4 5 6 7 8 9 RHE
Orioles
0 0 0 0 1 1 1 0 0 3 7 0
Guardians
1 0 1 0 1 2 1 0 X 6 7 0
Live Probabilities
Moneyline
Over / Under
Run Line
Orioles BAL
Win %
0%
100%
Guardians CLE
Win Probability
Last At Bat
Outs
Jackson Holliday lines out to right field to Nolan Jones.
Quick Box Score
Hitting
Pitching
Orioles Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 J. Holliday 2B40110100.250.650
2 J. Westburg DH400000100.000
3 G. Henderson SS200002000.500
4 R. Laureano RF41111020.251.250
5 C. Mullins CF400000400.000
6 R. Urías 3B41200010.51.000
7 C. Cowser LF40100010.250.500
8 C. Mayo 1B111003012.000
9 A. Jackson C100000000.000
Guardians Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 S. Kwan LF500000100.000
2 A. Martínez CF51310000.61.400
3 J. Ramírez 3B21111200.52.800
4 K. Manzardo DH30120010.3330.583
5 C. Santana 1B400000100.000
6 N. Jones RF310001200.250
7 D. Schneemann 2B21100210.51.250
8 B. Rocchio SS31120000.3330.666
9 B. Naylor C210002000.500

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Orioles vs. Guardians: Detailed Breakdown

Matchup Overview

  • Teams: Orioles vs. Guardians
  • Date: Tuesday, July 22, 2025
  • Time: 6:40 PM ET
  • Venue: Progressive Field

Current Betting Odds

  • Spread: Guardians favored at -1.5
  • Total (Over/Under): 8
  • Moneyline Odds: Orioles +140, Guardians -157

Dimers' Win Probabilities

  • Orioles: 41%
  • Guardians: 59%

Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Orioles a win probability of 41%, while the Guardians have a win probability of 59%. Discover the best spread, over/under, and moneyline odds for the game on this page.

Summary

According to our analysis, the Guardians are more likely to beat the Orioles in the MLB game at Progressive Field on Tuesday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Orioles vs. Guardians predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.

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