Northern Iowa vs. Southern Illinois Prediction, Picks and Odds

Northern Iowa vs. Southern Illinois: Detailed Breakdown

Matchup Overview

• Teams: Northern Iowa vs. Southern Illinois
• Date: Saturday, October 25, 2025
• Time: 3:00 PM ET
• Venue: Saluki Stadium

Current Betting Odds

• Spread: Southern Illinois favored at -14.5
• Total (Over/Under): 50.5
• Moneyline Odds: Northern Iowa +400, Southern Illinois -480

Dimers' Win Probabilities

• Northern Iowa: 17%
• Southern Illinois: 83%

Dimers' predictive model estimates win probabilities after simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view of each team's chances.

Projected Final Score

Our predicted final score for this college football matchup is Northern Iowa 19-33 Southern Illinois.

This prediction is based on each team's average score following 10,000 game simulations.

Our Prediction: Who Wins?

After extensive simulations, our model gives Northern Iowa a win probability of 17%, while Southern Illinois has a win probability of 83%.

Summary

According to our analysis, Southern Illinois is more likely to beat Northern Iowa in CFB action at Saluki Stadium on Saturday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Northern Iowa vs. Southern Illinois predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

Explore our expert college football predictions and the best college football bets today for more insights and betting opportunities.

Our in-depth analysis includes college football player props and college football futures, as well as constantly updated college football odds and the latest college football news.